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Thiofaco M-50: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Thiofaco M-50 - General Information

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem]

 

Pharmacology of Thiofaco M-50

Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm. This accounts for its bacteriocidal and antifungal action. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Ninety to 98% of ethanol that enters the body is completely oxidized. Thiofaco M-50 is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations.

 

Thiofaco M-50 for patients

 

Thiofaco M-50 Interactions

No information provided.

 

Thiofaco M-50 Contraindications

Subarachnoid injection of dehydrated alcohol is contraindicated in patients receiving anticoagulants because of the danger of bleeding.

 

Additional information about Thiofaco M-50

Thiofaco M-50 Indication

For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.

Mechanism Of Action
The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.
Generic Name
Ethanol
Synonyms
Absolute Alcohol; Absolute Ethanol; Alcohol; Alcohol Anhydrous; Alcohol, Dehydrated; Alcohol, Diluted; Alcool Ethylique; Alcool Etilico; Alkohol; Alkoholu Etylowego; Aminoethanol; Beta-Aminoethanol; Beta-Aminoethyl Alcohol; Beta-Ethanolamine; Beta-Hydroxyethylamine; Caswell No. 426; Dehydrated Ethanol; Denatured Alcohol; Denatured Ethanol; ETA; Etanolo; Ethanol 200 Proof; Ethanol Anhydrous; Ethanol Extra Pure; Ethyl Alcohol; Ethyl Alcohol Anhydrous; Ethyl Alcohol, Anhydrous; Ethyl Alcohol, Denatured; Ethyl Hydrate; Ethyl Hydroxide; Ethylolamine; Ethylol; Methylcarbinol; USAF EK-1597; HSDB 531
Drug Category
Solvents; Anti-Infective Agents, Local; Central Nervous System Depressants; Disinfectants
Drug Type
Small Molecule; Approved
Other Brand Names containing Ethanol
Aethanol; Aethylalkohol; Alcare Hand Degermer; Algrain; Anhydrol; Colamine; Denatured Alcohol Cd-10; Denatured Alcohol Cd-5; Denatured Alcohol Cd-5a; Denatured Alcohol Sd-1; Denatured Alcohol Sd-13a; Denatured Alcohol Sd-17; Denatured Alcohol Sd-23a; Denatured Alcohol Sd-28; Denatured Alcohol Sd-30; Denatured Alcohol Sd-39b; Denatured Alcohol Sd-39c; Denatured Alcohol Sd-3a; Denatured Alcohol Sd-40m; Envision Conditioner Pdd 9020; Ethamolin; Ethanol Absolute; Ethanol Absolute Bp; Ethanol, Silent Spirit; Ethyl Alcohol & Water, 10%; Ethyl Alcohol & Water, 20%; Ethyl Alcohol & Water, 30%; Ethyl Alcohol & Water, 40%; Ethyl Alcohol & Water, 5%; Ethyl Alcohol & Water, 50%; Ethyl Alcohol & Water, 60%; Ethyl Alcohol & Water, 70%; Ethyl Alcohol & Water, 80%; Ethyl Alcohol & Water, 95%; Ethyl Alcohol & Water, 96%; Glycinol; Jaysol; Jaysol S; Methylated Spirit Mineralised; Pyro; Reagent Alcohol; Spirit; Synasol; Tecsol; Tecsol C; Thanol; Thiofaco M-50;
Absorption
Rapidly absorbed.
Toxicity (Overdose)
Oral, rat LD50: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage.
Biotransformation
Hepatic. Metabolized by cytochrome P450 enzyme CYP2E1.
Dosage Forms of Thiofaco M-50
Liquid Topical
Chemical IUPAC Name
ethanol
Chemical Formula
C2H6O
Organisms Affected
Humans and other mammals